21c Museum Hotel Louisville Est. 2006

700 West Main Street, Louisville, KY, United States

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21c Museum Hotel Louisville
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Nine thousand sq. ft. of art-filled space sure does sound nice. 
Picture this. A still-life-come-to-real-life space with bespoke service and environmentally-sound options to green-up your gorgeous gathering. Truly the ideal, intimate soiree space for 10 or 450 of your closest friends. 
The Lowdown
Art Gallery
Historic Building
Hotel / Resort / Spa
Penthouse / Rooftop
Art Deco
Mid-Century Modern
Anniversary / Engagement Party
Corporate Event
Product Launch
Dinner Party
Rehearsal Dinner / Welcome Reception
Retreats: Corporate, Spa, Wellness, Etc.
Social Event
Wedding Ceremony
Wedding Reception

Venue Setting

Whatever the occasion, if you have the people, 21c Museum Hotel Louisville has the space that will ensure your gathering is the talk of the town. With over 9,000 square feet of art-filled event space, 21c is the ideal setting for weddings, board retreats, executive meetings, cocktail gatherings, reception dinners, charitable events, or any other special occasion.

Designed by renowned architect Deborah Berke, our accommodations in Louisville are spacious with high ceilings, large windows, and many guest rooms feature original exposed brick walls. 21c Louisville features an onsite restaurant, Proof on Main, in addition to a spa and a variety of other amenities designed to enhance the convenience of your stay. In addition to our premier guestrooms, our art hotel offers a delightful setting for guests to revel in thought-provoking art of the 21st century in our museum. 

Catering for events at 21c Museum Hotel Louisville is provided by Proof on Main, offering custom menus featuring the agricultural bounty of the Ohio River Valley and celebrating artisanal products and sustainable farming.

Thirsty? A variety of bar packages are available and Proof offers a carefully selected wine and spirits collection, highlighted by an impressive selection of 75+ of Kentucky’s finest bourbons, some bottled exclusively for Proof on Main.
(Prices listed here are estimates only & are subject to change)
Price Range

Does this include catering fees?


Estimated Price Per Head

from $18 to $250

Additional Charges

All event fees are subject to a 23% service charge, which includes setup, tear down and gratuity for event, and 6% Kentucky sales tax.


Additional Insurance Is Not Required To Host An Event Here


Celebrations Hosted Here Since
11 PM
Venue Spaces
Indoor & Outdoor Venue Spaces Available
Client Must Use The Catering Provided By The Venue
Provided By Venue For Fee – You Must Use The Venue For All Alcohol Services
Indoors & Outdoors
Non-smoking Venue
21c Museum Hotel Louisville offers 91 guest rooms, including 6 suites. 

For a completely immersive art exprience, book Asleep in the Cyclone. Created by New York-based artists Jonah Freeman and Justin Lowe, Asleep in the Cyclone is a site-specific sculptural installation that is also a functional hotel room.

Available for a truly luxurious stay or special event, the 21c Penthouse Apartment offers more than 1,300 square feet, plus a nearly 2,200 square foot rooftop garden terrace. This suite offers one bedroom with king bed, one full bath + two half baths, a full gourmet kitchen, open concept living/dining area, a private garden terrace with sweeping downtown views and a number of exclusive amenities. 
Eco/Green Events
Pet-Friendly Events
Kid Friendly Events
Handicap Accessible
  • A/V Equipment
  • Bridal Suite/Changing Rooms Onsite
  • Street Parking
  • Valet Parking
  • Wifi
  • Ample Parking Onsite
  • Dining Chairs
  • Dining Tables
  • Onsite Restrooms
  • Other
Awards & Notables2014 Global Vision Award Winner: Culture ​
Travel + Leisure
-“An innovative hotel brand turning unexpected American cities into art-driven destinations.”

Top 10 Hotels in the World
Condé Nast Traveler
Readers’ Choice Award
2009 / 2010 / 2011

Best Hotels in the South
Condé Nast Traveler
Readers’ Choice Award
2012 / 2013 / 2014 / 2015

Celebration Locations
2300 SQ FT
- Max Capacity: 500
The Galleries:
400 - 800 SQ FT
- Max Capacity: 75
Rooftop Apartment:
3511 SQ FT
- Max Capacity: 75
Private Dining Room at Proof on Main:
323 SQ FT
- Max Capacity: 24
Eats & Drinks
Food, Restaurants, Cafes, Bars & Lounges
Food, Restaurants, Cafes:

Proof on Main 

Lauded as one of Esquire magazine’s “Best New Restaurants,” Proof on Main in downtown Louisville’s acclaimed 21c Louisville is a favorite for locals and visitors alike. With a commitment to local farming, we deliver plates infused with local flavor. The bar is a local hot spot and features 75+ Kentucky Bourbons. Complimenting the culinary artistry, we feature rotating contemporary art exhibitions, curated by 21c Museum.

Bars & Lounges:

Celebrating Kentucky’s native spirit
Our spirit collection emphasizes small batch, artisanal craftsmanship from around the world. Given our proximity to Bourbon Country, it is naturally highlighted by an impressive selection of 75+ of Kentucky’s finest Bourbons, some bottled exclusively for Proof on Main including special barrels of Woodford Reserve and Van Winkle. Our signature cocktail list includes original recipes inspired by the season (and sometimes Current Exhibitions), making Proof an essential stop along Louisville’s Urban Bourbon Trail. Fresh juices, inventive infusions and housemade tonic are highlights of their signature offerings.

Beyond Bourbon
Wino forever? Our award-winning wine list is both accessible and eclectic. With a 100-bottle list that includes small boutique producers as well as more widely recognized brands, our international collection includes wines hailing from Italy, Spain, France, Australia, Germany, Austria and the United States, representing both “Old World” and “New World” styles of winemaking. An extensive and frequently changing selection of wines by the quartino are chosen to pair with our menu offerings.

Art-Filled After Party
Birthday Bucket List of the Week: Go to the Kentucky Derby with 21c Museum Hotel Louisville
Katie David Bush
byKatie David Bush
view venue profile

21c Museum Hotel Louisville

700 West Main Street, Louisville, KY, United States

“To all the ladies in the place with style and grace….”  If the month of May means pops of pastels, placin’ bets on ponies and raising a little hell with a beveled bourbon highball in hand…  all the while cocking your chic chapeau of course, this #BirthdayBucketList is for you. We’ve been chomping at the bit to put this gamblin’ gathering at the top of our #BirthdayBucketList but we figured in this case, slow and steady would win the race.

We wanted to unearth an experience worthy of your group of gorgeous gals where tradition took a bit of a turn… you didn’t think we’d be all big hats and mint juleps did ya? (Not to worry, both of these beautiful traditions remain solidly a part of this story) For this bucket list you’ll still worship at the alter of the Churchill Downs but your “Old Kentucky Home” is a decidedly more modern, chic and art-filled after party at relative new kid on the block, 21c Museum Hotel Louisville.

So gather your favorite guys and gals, grab those fabulous fascinators and head to Louisville to host a bourbon-filled bluegrass bash at the Derby and 21c – our cards are on the table and baby, they’re just showing hearts.  


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