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M Brothers at Mayo is a hidden gem tucked inside Jacksonville’s Mayo Clinic—a delightful reprieve where culinary excellence meets refined hospitality. A Medure Brothers Culinary Concept by acclaimed chefs Matthew and David Medure, M Brothers is led by Executive Chef Thomas Rivers and offers a sophisticated dining experience on Mayo Clinic's campus.Enjoy globally inspired cuisine crafted with seasonal ingredients, and don’t miss our monthly Culinary Passport tasting menus, where we explore flavors from a different region of the world each month.Visit our lounge for a handcrafted cocktail or select a bottle from our extensive wine list. Join us for Lunch Monday–Friday and Dinner Monday–Saturday. Unwind during Happy Hour in the lounge, Monday–Friday from 4–6 PM. Whether you're sampling guest favorites like our burrata appetizer, savory shrimp étouffée, or a seasonal chef-driven entrée, M Brothers is a destination worth discovering.